But in July last year, the Court of Arbitration for Sport (CAS) overturned the ruling after a complaint from Indian athlete Dutee Chand, who has the same condition as Semanya.CAS ruled that there is insufficient evidence to link hyperandrogenism to a competitive advantage, freeing Semenya to stop taking the hormone-limiting drugs.This forced Semenya to take drugs which lowered her hormone levels, reducing her muscle mass and affecting her performance.

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She also appeared in Lord of Illusions with Scott Bakula.

In an attempt to fight against typecasting after her Bond girl performance, Janssen began seeking out more intriguing support roles, appearing in John Irvin's City of Industry, Woody Allen's Celebrity, Robert Altman's The Gingerbread Man, and Ted Demme's Monument Ave. She later reprised the role in the 2003 sequel, X2 where her character shows signs of increasing powers but at the end of the film, she is presumably killed.

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After retiring from modelling in the early 1990s, Janssen had guest roles on several television series, including a starring role in the 1992 Star Trek: The Next Generation episode "The Perfect Mate", as empathic metamorph Kamala, opposite Patrick Stewart, with whom she later starred in the X-Men film series.

In 1995, Janssen appeared in Pierce Brosnan's first James Bond film, Golden Eye, as femme fatale Xenia Onatopp.

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