As of 2015, she was the highest-paid female athlete across all sports and was named Sportsperson of the Year by in 2015.

She is also the most recent player, together with her sister Venus Williams, to have held all four Grand Slam women's doubles titles simultaneously (2009–10).

Her total of 23 Grand Slam singles titles marks the record for the most Major wins by a tennis player in the Open Era, She is the only tennis player in history (man or woman) to have won singles titles at least six times in three of the four Grand Slam tournaments, and the only player ever to have won 2 of the 4 Majors 7 times each (7 Wimbledon titles and 7 Australian Open titles).

Williams holds the Open Era record for most titles won at the Australian Open (7) and shares the Open Era record for most titles won at the US Open with Chris Evert (6).

She also holds an all-time record for the most singles matches won at the Grand Slams (man or woman) with 316 matches (through the 2017 Australian Open).

She also came back from a 3–5 deficit in the third set against Kim Clijsters in the 1999 US Open and went on to win her first Grand Slam singles title.

In the 2012 US Open final against Victoria Azarenka, she was down 3–5 in the third set and found herself two points away from losing the match.

when she was nine so that she could attend the tennis academy of Rick Macci, who would provide additional coaching.

Macci spotted the exceptional talents of the sisters.

“I play for me,’’ Serena told , ‘‘but I also play and represent something much greater than me. “I don’t want to be like some of those celebrities walking around, just so full of themselves.