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They are transmitted by direct contact with body fluids or lesions of an infected individual.
In HSV-1-infected individuals, seroconversion after an oral infection prevents additional HSV-1 infections such as whitlow, genital herpes, and herpes of the eye.
Prior HSV-1 seroconversion seems to reduce the symptoms of a later HSV-2 infection, although HSV-2 can still be contracted.
Symptoms include fever, headache, sore throat, and swollen glands. A herpetic infection of the brain thought to be caused by the transmission of virus from a peripheral site on the face following HSV-1 reactivation, along the trigeminal nerve axon, to the brain.
HSV is the most common cause of viral encephalitis.
On occasion, infection occurs on the toes or on the nail cuticle.
Individuals who participate in contact sports such as wrestling, rugby, and football(soccer), sometimes acquire a condition caused by HSV-1 known as herpes gladiatorum, scrumpox, wrestler's herpes, or mat herpes, which presents as skin ulceration on the face, ears, and neck.One of the most striking is the appearance of clean linear erosions in skin creases, with the appearance of a knife cut.Herpetic keratoconjunctivitis, a primary infection, typically presents as swelling of the conjunctiva and eyelids (blepharoconjunctivitis), accompanied by small white itchy lesions on the surface of the cornea.Many people infected with HSV-2 display no physical symptoms—individuals with no symptoms are described as asymptomatic or as having subclinical herpes.Herpes whitlow is a painful infection that typically affects the fingers or thumbs.Genital herpes is classified as a sexually transmitted infection. The diagnosis may be confirmed by viral culture or detecting herpes DNA in fluid from blisters.