Background and Objective: Hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) grafts have shown to be effective in promoting the clinical signs of periodontal regeneration in intrabony defects.The aim of our study was to clinically and radiographically evaluate the efficacy of HA and β-TCP composite bone graft material in the treatment of intrabony three-wall defect.

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All the differences were highly significant and in favor of postoperative group.

Conclusion: The results of this study suggest that HA-βTCP (biphasic calcium phosphate) provides an added regenerative effect in promoting the clinical resolution of intrabony three-wall defects in patients with periodontitis.

The ultimate goal of periodontal therapy is to regenerate the lost periodontal tissue for optimal function and esthetic.

For regeneration, growth, and differentiation, cells and intercellular substances are required to form new tissues or parts; to achieve tissue regeneration, the cells in the wound must be of the same type and must be oriented in the same pattern as the original cells.

Therefore, it is believed that this material produces a response like a well-tolerated foreign body within the host connective tissue.

β- TCP was reported to form bone within the periodontal osseous defects, but the new attachment was questionable.Thus, development of a two-phased calcium phosphate or biphasic calcium phosphate (BCP) ceramic made it possible to control the resorbability of the material and at the same time maintain its osteoconductive property.This ceramic might be classified as resorbable because of the β-TCP content (it is known that β-TCP resorbs much faster); the presence of HA in the structure retards the resorbability of the material.Although these materials offer a solution to some of the above problems, the question of immunogenicity and disease transfer had often been raised.Therefore, considering all the above-mentioned problems, alloplastic materials were introduced.99% crystalline structure consists of 60% HA and 40% β-TCP in particulate form and was introduced as a grafting material in periodontal, peri-implant, and various types of bone defects.