Actors Ellen Pompeo, Sandra Oh, Katherine Heigl, Justin Chambers, and T. Knight reprised their roles as surgical interns Meredith Grey, Cristina Yang, Izzie Stevens, Alex Karev, and George O'Malley, respectively.

The season saw numerous cast and crew members receive awards and nominations at ceremonies like the 58th Primetime Emmy Awards and the 64th Golden Globe Awards.

Katherine Heigl and Chandra Wilson were the cast members with the most nominations for their portrayals of Izzie Stevens and Miranda Bailey, respectively.

The second season of the American television medical drama Grey's Anatomy commenced airing on the American Broadcasting Company (ABC) on September 25, 2005, and concluded on May 15, 2006.

The season was produced by Touchstone Television, in association with Shondaland production company and The Mark Gordon Company, the showrunner being Shonda Rhimes.

The season includes the first episode to be written Zoanne Clack, who would become one the series' main writers, as well as a co-producer and executive story editor.

Other writers include Kip Koenig, Blythe Robe and Elizabeth Klaviter.

Bailey in his recently introduced role as Joe the Bartender.

"Straight to Heart" aired one week before the winter-holiday hiatus ended, recapping the most memorable events of the first season and the first half of the second.

Executive producer Peter Horton returned to the series to direct five episodes for the season, after writing two episodes in the second season.